Regulation of Gene Expression in Eukaryotic Cells
Research in the lab focuses on learning how cells control gene activity so they can grow and thrive, and how cells alter gene activity when they encounter changes in the environment so they can adapt and survive. We focus on two main research areas: (1) detailing the molecular processes involved in gene activation and transcription, and (2) understanding how cells use SUMO post-translational modifications to regulate gene expression. Primarily, we use budding yeast, a popular model organism, as our biological system and our methodologies include a combination of molecular biology, biochemistry, yeast genetics, and genome-scale technologies.
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